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KMID : 0370219910350050389
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Yakhak Hoeji
1991 Volume.35 No. 5 p.389 ~ p.393
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Facile Synthesis of (±)-2-[p-(1-Oxo-2-isoindolinyl)phenyl] butyric acid (Indobufen)
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Abstract
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Indobufen;a potent antiinflammatory agent;ethyl 2-phenylbutyrate;Friedei-Crafts reaction;ethylation;desulfurization;ethyl 2-(p-aminophenyl) butyrate;nitration;reduction;condensation reaction;hydrolysis
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